The value of PD-L1 immunohistochemical expression in Egyptian urinary bladder carcinoma patients

Evaluation of the prognostic value of CD117 and CK20 biomarkers in urinary bladder carcinoma

Background: Over-expression of CD117 and cytokeratin 20 (CK20) is seen in many malignancies. Given that few studies have been conducted regarding the role of these biomarkers in the etiology of bladder tumours, this study aimed to evaluate the prognostic value of CD117 and CK 20 biomarkers in the benign and malignant tumours of urinary bladder carcinoma. Methods: This case-control study was co...

Over-Expression of Immunosuppressive Molecules, PD-L1 and PD-L2, in Ulcerative Colitis Patients

Immunohistochemical Expression of Pd-l1 in Solid Tumors

Recent clinical trials have demonstrated that it is possible to induce durable remission in several tumors (non-small cell lung cancer (NSCLC), melanoma, squamous cancer of head and neck, renal cell carcinoma, Hodgkin lymphoma, colorectal cancer) by blocking the PD-1/PD-L1 (programmed death-1/programmed death-ligand 1) axis with anti-PD-1 or antiPD-L1 antibodies and that an objective clinical r...

Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder.

Urothelial carcinoma is a common malignant neoplasm that has a poor prognosis and a high frequency of recurrence and metastasis. Constant disease surveillance with periodic and long term cystoscopy examination is necessary for management of the disease. However, the monitoring and therapy regimen is expensive, incurring a massive burden to patients and the government. Therefore, the development...

Immunohistochemical Maspin Expression in Transitional Cell Carcinoma of the Bladder.

PURPOSE Evaluation of Maspin marker in TCC of urine bladder, its grade, and stage, and also to compare Maspin expression in normal transitional cell epithelium and TCC in patients admitted to Modarres Hospital from 2009 to 2012. MATERIALS & METHODS Paraffin blocks of bladder tissue, from total number of 76 patients with TCC, and normal epithelium were included. Slides were prepared, and stain...